2021
- Agola JO, Dunphy D, Salazar M, Jett S, Theron C, Pokhrel S, Mädler L, Prossnitz A, Croissant J, Noureddine A, Durfee P, McGregor T, Holden PA, Li R, Nel A, Brinker CJ Rare earth elements dephosphorylate bacterial cell membranes via formation of REPO4 nanocrystals creating new phenotypes. Nature Commun (under revision)
- Balakrishnan A, Groeneveld JD, Pokhrel S, Mädler L. Metal Sulfide Nanoparticles: Precursor Chemistry. Chem Eur J 27:21 (2021) 6390;
https://doi.org/10.1002/chem.202004952 - Binder K, Bonatto Minella C, Elberskirch L, Kraegeloh A, Liebing J, Petzold C, Razum M, Riefler N, Schins R, Sofranko A, van Thriel C, Unfried K. Discussion on Existing Standards and Quality Criteria in Nanosafety Research – Summary of the NanoS-QM Expert Workshop.
https://doi.org/10.5281/zenodo.4584789 - Bredeck G, Kämpfer AAM, Sofranko A, Wahle T, Lison D, Ambroise J, Stahlmecke B, Albrecht C, Schins RPF, Effects of dietary exposure to the engineered nanomaterials CeO 2 , SiO 2 , Ag, and TiO 2 on the murine gut microbiome. Nanotoxicology 15:7 (2021) 934
https://doi.org/10.1080/17435390.2021.1940339 - Busch M, Kämpfer AAM, Schins RPF, An inverted in vitro triple culture model of the healthy and inflamed intestine: Adverse effects of polyethylene particles. Chemosphere 284 (2021) 131345
https://doi.org/10.1016/j.chemosphere.2021.131345 - Gomes SIL, Amorim MJB, Pokhrel S, Mädler L, Fasano M, Chiavazzo E, et al. Machine learning and materials modelling interpretation of in vivo toxicological response to TiO 2 nanoparticles library (UV and non-UV exposure). Nanoscale 13:35 (2021) 14666
https://doi.org/10.1039/D1NR03231C - Gottschling S, Kammerer Y, Readers’ Regulation and Resolution of a Scientific Conflict Based on Differences in Source Information: An Eye-Tracking Study. Discourse Process 58:5–6 (2021): 468
https://doi.org/10.1080/0163853X.2021.1930808 - Kämpfer AAM, Busch M, Büttner V, Bredeck G, Stahlmecke B, Hellack B, Masson I, Sofranko A, Albrecht C, Schins RPF, Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models. Small 17:15 (2021) 2004223
https://doi.org/10.1002/smll.202004223 - Kammerer Y, Gottschling S, Bråten I, The Role of Internet-Specific Justification Beliefs in Source Evaluation and Corroboration During Web Search on an Unsettled Socio-Scientific Issue. J Edu Comput Res 59:2 (2021) 342
https://dx.doi.org/10.1177/0735633120952731 - Llewellyn SV, Kämpfer A, Keller JG, Vilsmeier K, Büttner V, Ag Seleci D, Schins RPF, Doak SH, Wohlleben W, Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required? Small 17:15 (2021) 2004630
https://doi.org/10.1002/smll.202004630 - Lotz A, Pesch B, Casjens S, Lehnert M, Zschiesche W, van Thriel C, Brüning T, Behrens T, Association of exposure to manganese and fine motor skills in welders – results from the WELDOX II study. Neurotoxicology 82 (2021) 137
https://dx.doi.org/10.1016/j.neuro.2020.12.003 - Meziu E, Koch M, Fleddermann J, Schwarzkopf K, Schneider M, Kraegeloh A, Visualization of the structure of native human pulmonary mucus. Int J Pharm 597 (2021) 120238
https://doi.org/10.1016/j.ijpharm.2021.120238 - Schalk M, Pokhrel S, Schowalter M, Rosenauer A, Mädler L, Control of Porous Layer Thickness in Thermophoretic Deposition of Nanoparticles. Materials 14:9 (2021) 2395
https://doi.org/10.3390/ma14092395 - Sofranko A, Wahle T, Heusinkveld HJ… Schins RPF, Evaluation of the Neurotoxic Effects of Engineered Nanomaterials in C57BL/6J Mice in 28-Day Oral Exposure Studies. NeuroToxicology 84 (2021) 155
https://doi.org/10.1016/j.neuro.2021.03.005 - Stodt MFB, Liu C, Li S, Mädler S, Fritsching U, Kiefer J, Phase-selective laser–induced breakdown spectroscopy in flame spray pyrolysis for iron oxide nanoparticle synthesis. Proc Combust Inst 38:1 (2021) 1711
https://doi.org/10.1016/j.proci.2020.06.092 - Swanson HL, Pokhrel S, Davidowski SK, Mädler L, Brinker CJ, Holland GP, The Impact of Metal Doping on Fumed Silica Structure and Amino Acid Thermal Condensation Catalytic Properties. J Mater Sci 56:30 (2021) 16916
https://doi.org/10.1007/s10853-021-06412-0 - Tacu I, Kokalari I, Abollino O, Albrecht C, Malandrino M, Ferretti AM, Schins RPF, Fenoglio I, Mechanistic Insights into the Role of Iron, Copper, and Carbonaceous Component on the Oxidative Potential of Ultrafine Particulate Matter. Chem Res Toxicol 34:3 (2021) 767
https://doi.org/10.1021/acs.chemrestox.0c00399 - Tavernaro I, Dekkers S, Soeteman-Hernández LG, Herbeck-Engel P, Noorlander C, Kraegeloh A,Safe-by-Design Part II: A Strategy for Balancing Safety and Functionality in the Different Stages of the Innovation Process. NanoImpact 24 (2021) 100354
https://doi.org/10.1016/j.impact.2021.100354
2020
- Abdulnasser Harfoush S, Hannig M, Le DD, Sebastian Heck, Leitner M, Omlor AJ, Tavernaro I, Kraegeloh A, Kautenburger R, Kickelbick G, Beilhack A, Bischoff M, Nguyen J, Sester M Bals R, Dinh QT, High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice. Respir Res 21 (2020) 168
https://doi.org/10.1186/s12931-020-01386-0 - Boyes WK, van Thriel C, Neurotoxicology of nanomaterials. Chem Res Toxicol 33 (2020) 1121
https://dx.doi.org/10.1021/acs.chemrestox.0c00050 - Dekkers S, Wijnhoven SWP, Braakhuis HM, Soeteman-Hernandez LG, Sips AJAM, Tavernaro I, Kraegeloh A, Noorlander CW, Safe-by-Design part I: Proposal for nanospecific human health safety aspects needed along the innovation process. NanoImpact 18 (2020) 100227.
https://doi.org/10.1016/j.impact.2020.100227 - Gottschling S, Kammerer Y, Thomm E, Gerjets P, How Laypersons Consider Differences in Sources’ Trustworthiness and Expertise in their Regulation and Resolution of Scientific Conflicts. Int J Sci Ed B 10:4 (2020) 335
https://doi.org/10.1080/21548455.2020.1849856 - Höller RPM, Kuttner C, Mayer M, Wang R, Dulle M, Contreras-Caceres R, Fery A, Colloidal superstructures with triangular cores: Size effects on SERS efficiency. ACS Photonics 7 (2020) 1839
https://doi.org/10.1021/ACSPHOTONICS.0C00642 - Joshi A, Naatz H, Faber K, Pokhrel S, Dringen R, Iron-Doping of Copper Oxide Nanoparticles Lowers Their Toxic Potential on C6 Glioma Cells. Neurochem Res 45 (2020) 809
https://doi.org/10.1007/s11064-020-02954-y - Kämpfer AAM, Busch M, Schins RPF, Advanced in vitro testing strategies and models of the intestine for nanosafety research. Chem Res Toxicol 33:5 (2020) 1163
https://doi.org/10.1021/acs.chemrestox.0c00079 - Krug H, Kraegeloh A, Special Issue on “Future Nanosafety”. Chem Res Toxicology 33:5 (2020) 1037
https://doi.org/10.1021/acs.chemrestox.0c00166 - Li Y, Pionteck J, Pötschke P, Voit B, Thermal annealing to influence the vapor sensing behavior of co-continuous poly(lactic acid)/polystyrene/multiwalled carbon nanotube composites. Mater Des 187 (2020) 108383
https://doi.org/10.1016/J.MATDES.2019.108383 - Li Y, Zheng YJ, Pionteck J, Voit B, Tuning the structure and performance of bulk and porous vapor sensors based on co-continuous carbon nanotube-filled Blends of poly(vinylidene fluoride) and polycarbonates by varying melt viscosity ACS Appl Mat Interf 12 (2020) 45404
https://doi.org/10.1021/ACSAMI.0C15184 - Liu C, Pokhrel S, Tessarek C, Li H, Schowalter M, Rosenauer A, Eickhoff M, Li S, Mädler L, Rare-Earth-Doped Y4Al2O9 Nanoparticles for Stable Light-Converting Phosphors. ACS Applied Nano Materials 3:1 (2020) 699
https://doi.org/10.1021/acsanm.9b02231 - Liu X, Feng Y, Jin L, Wang X, Zhang X, Xie Y, Zhao C, Appelhans D, Voit B, Rapid synthesis of PEGylated multiblock polymers by sequence-controlled polymerization in H2O. Polymer Chem 11 (2020) 417
https://doi.org/10.1039/C9PY01202H - Naatz H, Manshian BB, Rios Luci C, Tsikourkitoudi V, Deligiannakis Y, Birkenstock J, Pokhrel S, Mädler L, Soenen SJ, Model‐Based Nanoengineered Pharmacokinetics of Iron‐Doped Copper Oxide for Nanomedical Applications. Angew Chem Int Ed 59 (2020) 1828
https://doi.org/10.1002/anie.201912312 - Okulov IV, Joo S-H, Okulov AV, Volegov AS, Luthringer B, Willumeit-Römer R, Zhang L, Mädler L, Eckert J, Kato H, Surface Functionalization of Biomedical Ti-6Al-7Nb Alloy by Liquid Metal Dealloying. Nanomaterials 10:8 (2020) 1479
https://doi.org/10.3390/nano10081479 - Peng G, He Y, Wang X, Cheng Y, Zhang H, Savolainen K, Mädler L, Pokhrel S, Lin S, Redox Activity and Nano–Bio Interactions Determine the Skin Injury Potential of Co3O4-Based Metal Oxide Nanoparticles toward Zebrafish. ACS Nano 14:4 (2020) 4166
https://doi.org/10.1021/acsnano.9b08938 - Pokhrel S, Mädler L, Flame-made Particles for Sensors, Catalysis, and Energy Storage Applications. Energy Fuels 34:11 (2020) 13209
https://doi.org/10.1021/acs.energyfuels.0c02220 - Rossner C, Fery A, Planet-satellite nanostructures from inorganic nanoparticles: from synthesis to emerging applications. MRS Commun 10 (2020) 112
https://doi.org/10.1557/MRC.2019.163 - Stodt MFB, Liu C, Li S, Mädler L, Fritsching U, Kiefer J, Phase-selective laser–induced breakdown spectroscopy in flame spray pyrolysis for iron oxide nanoparticle synthesis.em> Proceedings of the Combustion Institute (in press)
https://doi.org/10.1016/j.proci.2020.06.092 - Tang X, Pötschke P, Pionteck J, Li Y, Formanek P, Voit B, Tuning the piezoresistive behavior of poly(vinylidene fluoride)/carbon nanotube composites using poly(methyl methacrylate). ACS Appl Mat Interf 12 (2020) 43125
https://doi.org/10.1021/ACSAMI.0C11610 - Wahle T, Sofranko A, Dekkers S, Miller MR, Heusinkveld HJ, Albrecht C, Cassee FR, Schins RPF, Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer’s and vascular disease. Neurochem Int 138 (2020) 104755
https://doi.org/10.1016/j.neuint.2020.104755
2019
- Fleddermann J, Susewind J, Peuschel H, Koch M, Tavernaro I, Kraegeloh A, Distribution of SiO2 nanoparticles in 3D liver microtissues. Int J Nanomed 14 (2019) 1411
https://doi.org/10.2147/IJN.S189888 - Gottschling S, Kammerer Y, Gerjets P, Readers’ Processing and Use of Source Information as a Function of Its Usefulness to Explain Conflicting Scientific Claims. Discourse Process 56:5-6 (2019) 429
https://doi.org/10.1080/0163853X.2019.1610305 - Kasper JY, Hermanns MI, Kraegeloh A, Roth W, Kirkpatrick CJ, Unger RE, In Vitro Entero-Capillary Barrier Exhibits Altered Inflammatory and Exosomal Communication Pattern after Exposure to Silica Nanoparticles. Int J Mol Sci 20:13 (2019) 3301
https://doi.org/10.3390/ijms20133301 - Krug H, Kraegeloh A, Nanosafety: Where Are We Now and Where Must We Go? Chem Res Toxicol 32:4 (2019) 535
https://doi.org/10.1021/acs.chemrestox.9b00083 - Çakmak G, Ertürk P, Emerce E, Arı A, Odabaşı M, Schins RPF, Burgaz S, Gaga EO, Investigation of spatial and temporal variation of particulate matter in vitro genotoxicity and cytotoxicity in relation to the elemental composition. Mutat Res – Genetic Toxicology and Environmental Mutagenesis 842 (2019) 22
https://doi.org/10.1016/j.mrgentox.2019.01.009 - Pavan C, Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison D, Lo Giudice C, Martra G, Montfort E, Schins R, Sulpizi M, Wegner K, Wyart-Remy M, Ziemann C, Turci F The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity? Part Fibre Toxicol 16:1 (2019) 32.
https://doi.org/10.1186/s12989-019-0315-3 - Piché D, Tavernaro I, Fleddermann J, Lozano JG, Varambhia A, Maguire ML, Koch M, Ukai T, Hernández Rodríguez HJ, Jones L, Dillon F, Molina IR, Mitzutani M, González Dalmau ER, Maekawa T, Nellist PD, Kraegeloh A, Grobert N, Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles. ACS Appl Mater Interfaces 11:7 (2019) 6724
https://doi.org/10.1021/acsami.8b17162 - Schmitz C, Welck J, Tavernaro I, Grinberg M, Rahnenführer J, Kiemer AK, van Thriel C, Hengstler JG, Kraegeloh A, Mechanical strain mimicking breathing amplifies alterations in gene expression induced by SiO2 NPs in lung epithelial cells. Nanotoxicology 13:9 (2019) 1227
https://doi.org/10.1080/17435390.2019.1650971 - Silva C, Simon F, Friedel P, Pötschke P, Zimmerer C, Elucidating the chemistry behind the reduction of graphene oxide using a green approach with polydopamine. Nanomaterials 9 (2019) 902.
https://dx.doi.org/10.3390%2Fnano9060902 - Soeteman-Hernandez LG, Apostolova MD, Bekker C, Dekkers S, Grafström RC, Groenewold M, Handzhiyski Y, Herbeck-Engel P, Hoehener K, Karagkiozaki V, Kelly S, Kraegeloh A, Logothetidis S, Micheletti C, Nymark P, Oomen A, Oosterwijk T, Rodríguez-Llopis I, Sabella S, Sanchez Jiménez A, Sips AJAM, Suarez-Merino B, Tavernaro I, van Engelen J, Wijnhoven SWP, Noorlander CW, Safe Innovation Approach: Towards an agile system for dealing with innovations. Mater Today Commun 20 (2019) 100548
https://doi.org/10.1016/j.mtcomm.2019.100548 - Soppa VJ, Shinnawi S, Hennig F, Sasse B, Hellack B, Kaminski H, Quass U, Schins RPF, Kuhlbusch TAJ, Hoffmann B, Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness – A randomized sham-controlled exposure study Int J Hyg Environ Health 222:8 (2019) 1115
https://doi.org/10.1016/j.ijheh.2019.08.002 - Spannbrucker T, Ale-Agha N, Goy C, Dyballa-Rukes N, Jakobs P, Jander K, Altschmied J, Unfried K, Haendeler J, Induction of a senescent like phenotype and loss of gap junctional intercellular communication by carbon nanoparticle exposure of lung epithelial cells. Experimental Gerontology 117 (2019) 106
https://doi.org/10.1016/j.exger.2018.11.017
2018
- Kraegeloh A, Suarez-Merino B, Sluijters T, Micheletti C, Implementation of Safe-by-Design for Nanomaterial Development and Safe Innovation: Why We Need a Comprehensive Approach. Nanomaterials 8:4 (2018) 239
https://doi.org/10.3390/nano8040239 - Manshian BB, Pokhrel S, Mädler L, Soenen SJ, The impact of nanoparticle-driven lysosomal alkalinization on cellular functionality. J Nanobiotech 16 (2018) 85
https://doi.org/10.1186/s12951-018-0413-7 - Zampardi G, Thöming J, Naatz H, Amin HMA, Pokhrel S, Mädler L, Compton RG, Electrochemical Behavior of Single CuO Nanoparticles: Implications for the Assessment of their Environmental Fate. Small 14 (2018) 1801765
https://doi.org/10.1002/smll.201801765 - Stöckmann D, Spannbrucker T, Ale-Agha N, Jakobs P, Goy C, Dyballa-Rukes N, Hornstein T, Kümper A, Kraegeloh A, Haendeler J, Unfried K, Non-Canonical Activation of the Epidermal Growth Factor Receptor by Carbon Nanoparticles. Nanomaterials 8:4 (2018) 267
https://doi.org/10.3390/nano8040267 - Hanžić N, Horvat A, Bibić J, Unfried K, Jurkin T, Dražić G, Marijanović I, Slade N, Gotić M, Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation. Materials Science & Engineering C 91 (2018) 486–495
https://doi.org/10.1016/j.msec.2018.05.066 - Lindner K, Webering S, Stroebele M, Bockhorn H, Hansen T, König P, Fehrenbach H, Low Dose Carbon Black Nanoparticle Exposure Does Not Aggravate Allergic Airway Inflammation in Mice Irrespective of the Presence of Surface Polycyclic Aromatic Hydrocarbons. Nanomaterials 8:4 (2018) 213
https://doi.org/10.3390/nano8040213 - Casjens S, Dydak U, Dharmadhikari S, van Thriel C, Herrmann L, Muhlack S, Woitalla D, Aschner M, Brüning T, Pesch B, Association of exposure to manganese and iron with striatal and thalamic GABA and other neurometabolites – Neuroimaging results from the WELDOX II study. Neurotoxicology 64 (2018) 60
https://doi.org/10.1016/j.neuro.2017.08.004 - Pesch B, Dydak U, Lotz A, van Thriel C, Herrmann L, Muhlack S, Woitalla D, Glaubitz B, Schmidt-Wilcke T, Brüning T, Association of exposure to manganese and iron with relaxation rates R1 and R2*- magnetic resonance imaging results from the WELDOX II study. Neurotoxicology 64 (2018) 68
https://doi.org/10.1016/j.neuro.2017.08.008 - Dekkers S, Ma-Hock L, Lynch I, Russ M, Miller MR, Schins RPF, Keller J, Römer I, Küttler K, Strauss V, De Jong WH, Landsiedel R, Cassee FR, Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms. Inhalation Toxicology 30:7-8 (2018) 273
https://doi.org/10.1080/08958378.2018.1516834 - Ispanixtlahuatl-Meráz O, Schins RPF, Chirino YI, Cell type specific cytoskeleton disruption induced by engineered nanoparticles. Environ. Sci.: Nano 5 (2018) 228
https://doi.org/10.1039/C7EN00704C
2017
- Schmidt S, Tavernaro I, Cavelius C, Weber E, Kümper A, Schmitz C, Fleddermann J, Kraegeloh A, Silica Nanoparticles for Intracellular Protein Delivery: a Novel Synthesis Approach Using Green Fluorescent Protein. Nanoscale Research Letters 12:1 (2017) 545
https://doi.org/10.1186/s11671-017-2280-9 - Hellack B, Nickel C, Albrecht C, Kuhlbusch TAJ, Boland S, Baeza-Squiban A, Wohlleben W, Schins RPF, Analytical methods to assess the oxidative potential of nanoparticles: a review. Environmental Science: Nano 4 (2017) 1920
https://doi.org/10.1039/C7EN00346C - Hellack B, Nickel C, Schins RPF, Oxidative potential of silver nanoparticles measured by electron paramagnetic resonance spectroscopy. J Nanoparticle Res 19 (2017) 404
https://doi.org/10.1007/s11051-017-4084-3 - Kraegeloh A, Unfried K, The Safety of Nanomaterials on Molecular and Cellular Scale. in: The Nanomaterials Handbook, Second Edition, edited by Yury Gogotsi, June 29, 2017, CRC Press
https://doi.org/10.1201/9781315371795-22 - van Thriel C, Quetscher C, Pesch B, Lotz A, Lehnert M, Casjens S, Weiss T, Van Gelder R, Plitzke K, Brüning T, Beste C, Are multitasking abilities impaired in welders exposed to manganese? Translating cognitive neuroscience to neurotoxicology. Arch Toxicol 91 (2017) 2865
https://doi.org/10.1007/s00204-017-1932-y - Lindner K, Ströbele M, Schlick S, Webering S, Jenckel A, Kopf J, Danov O, Sewald K, Buj C, Creutzenberg O, Tillmann T, Pohlmann G, Ernst H, Ziemann C, Hüttmann G, Heine H, Bockhorn H, Hansen T, König P, Fehrenbach H, Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons. Part Fibre Toxicol 14:1 (2017) 8
https://doi.org/10.1186/s12989-017-0189-1 - Tavernaro I, Cavelius C, Peuschel H, Kraegeloh A, Bright fluorescent silica-nanoparticle probes for high-resolution STED and confocal microscopy. Beilstein J Nanotechnol 8 (2017) 1283
https://doi.org/10.3762/bjnano.8.130
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https://doi.org/10.1016/j.actbio.2014.11.009 - Hoppstädter J, Seif M, Dembek A, Cavelius C, Huwer H, Kraegeloh A, Kiemer AK, M2 polarization enhances silica nanoparticle uptake by macrophages. Front Pharmacol 6 (2015) 55
https://doi.org/10.3389/fphar.2015.00055 - Autengruber A, Sydlik U, Kroker M, Hornstein T, Ale-Agha N, Stöckmann D, Bilstein A, Albrecht D, Paunel-Görgülü A, Suschek CV, Krutmann J, Unfried K, Signalling-Dependent Adverse Health Effects of Carbon Nanoparticles Are Prevented by the Compatible Solute Mannosylglycerate (Firoin) In Vitro and In Vivo. PLOS ONE 9:11 (2014) e111485
https://doi.org/10.1371/journal.pone.0111485 - van Berlo D, Wilhelmi V, Boots AW, Hullmann M, Kuhlbusch TAJ, Bast A, Schins RPF, Albrecht C, Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung. Arch Toxicol 88 (2014) 1725.
https://doi.org/10.1007/s00204-014-1220-z - Kucki M, Cavelius C, Kraegeloh A, Interference of silica nanoparticles with the traditional Limulus amebocyte lysate gel clot assay. Innate Immunity 20:3 (2014) 327.
https://doi.org/10.1177/1753425913492833 - Büchner N, Ale-Agha N, Jakob S, Sydlik U, Kunze K, Unfried K, Altschmied J, Haendeler J, Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes. Experimental Gerontology 48:1 (2013) 8.
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